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Corrado, A

Acts through Gq/PLC signaling and intracellular calcium mobilization in receptor-expressing cell models

Large-scale clinical trials and real-world data have documented higher rates of gallbladder events in patients taking these medications compared to control groups

Larger trials provide more statistical power and are better at detecting rarer side effects or identifying which patient subgroups respond best

As we age, chromatin tends to become heterochromatic: densely packed, transcriptionally silent, and resistant to repair [34]

They interfere with immune cell function and can alter cytokine production, disrupting the bodys ability to mount an effective immune response