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Nam H, Lim JH, Kim TW et al (2023) Extracellular superoxide dismutase attenuates hepatic oxidative stress in nonalcoholic fatty liver disease through the adenosine monophosphate-activated protein kinase activation

The most common side effects reported in trials include mild to moderate gastrointestinal issues: nausea, diarrhea, vomiting, and constipation

doi: 10.1016/j.kint.2019.07.025 34 MoriYAjayAKChangJHMouSZhaoHKishiSet al

The clinical review is dated July 22, 2026

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The targeted 3-PLG-ibu-A-GSH and ibuprofen at higher, 1.5 M concentration (the estimated drug content of the 3-PLG-ibu-A-GSH nanocarriers) significantly protected against the barrier damaging effect of cytokines with the ibuprofen-coupled targeted nanocarrier group showing the highest effect against BBB dysfunction (Fig