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In terms of PT-141s long-term safety for treating HSDD, researchers noted that of the 856 eligible patients who completed a 24-week double-blind core Phase 3 trial in 2015, 684 patients elected to participate in the 52-week open-label extension, and 272 completed it

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doi:10.1007/978-3-319-31738-0_114-1

The expression profile of genes monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF), tumor necrosis factor receptor type 1 (TNFR1), transforming growth factor-beta-1 (TGF1), collagen type I alpha 1 chain (Col1,) actin alpha 2 smooth muscle (SMA), tissue inhibitor of metalloproteinases 1 (Timp1), and haptoglobin (Hp) associated with non-alcoholic fatty liver disease (NAFLD) were elevated in the livers of mice fed an HFD for 16 weeks compared with those from mice fed the control diet (Fig