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References Afrin, L.B., Weinstock, L.B., & Dempsey, T.T

Sulfate-reducing bacteria in the colon consume sulfate that would otherwise be available for PAPS synthesis and sulfation

Orforglipron, an oral small-molecule GLp-1 receptor agonist for obesity treatment

Individuals with a homozygous A allele of the CYP1A2 gene tend to produce more cytochrome P450, an enzyme responsible for about 95% of caffeine metabolism, and consequently metabolize CAF more quickly

A higher HRV indicates a more resilient and adaptable nervous system, capable of calming the hyperadrenergic state that drives the severe tachycardia and palpitations experienced by POTS patients