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Unlike the acute setting, however, prolonged ablation of GSH synthesis in the liver resulted in decreased abundance of epididymal white adipose depots, a major storage tissue for triglycerides (Fig

Mustacich D (2001)

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The allosteric regulators of GLUD1 - ADP, GTP, Leu, NAD + and NADH - exert their effects by changing the energy required to open and close the catalytic cleft during enzymic turnover, in other words by destabilizing or stabilizing, respectively, the abortive complexes