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Both compounds benefit from robust hydration: semaglutide can reduce appetite and inadvertently lower fluid intake, while creatine requires adequate water to transport into muscle cells and protect kidney function

Canuto R, Garcez A, Vieira de Souza R, Kac G, Teresa Anselmo Olinto M

Arterioscler Thromb Vasc Biol (2015) 35:210413

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CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

3 Important safety information: Wegovy (semaglutide) is a prescription-only medication for managing obesity