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Acute administration of semaglutide, tirzepatide, and retatrutide each attenuated alcohol discrimination across multiple doses, suggesting that blunting or altering subjective alcohol effects could be a common target of this drug class

How they work Semaglutide, tirzepatide and retatrutide are all separate medicines that work in their own way

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4 Retatrutide has none of these yet, and the realistic UK approval window is late 2027 to mid 2028, with NHS access from 2029 at the earliest