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B., Suter, T
Starting doses typically begin low and gradually increase over several weeks to minimize gastrointestinal side effects like nausea, which are the most common complaint during the first few weeks of treatment
The standard approach involves gradual dose escalation, starting at 0.25 mg weekly for four weeks, then increasing to 0.5 mg weekly
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It may increase the blood-thinning effects of anticoagulants like Warfarin (Coumadin), requiring careful monitoring of prothrombin times and bleeding risks
Luli, M
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