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The OASIS 4 trial, published in 2025, found that the 25-milligram oral dose of semaglutide produced an average weight loss of 13.6% over 68 weeks
That might mean staying on GLP-1s long-term or transitioning to another medication strategy
The belly flattens
This delay in treatment can make it harder to reach goals
Once-monthly dosing could dramatically improve adherence -- a major barrier in chronic weight management
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