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This can lead to severe dehydration, malnutrition, or even more serious complications like gastroparesis, which is a condition where the stomach stops moving food through properly
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Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction
One is semaglutide, sold by Danish pharmaceutical giant Novo Nordisk as Rybelsus (oral) and Wegovy (injectable) - while Ozempic (injectable) has been approved for diabetes in India but is not yet available for obesity
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