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It is also advised to avoid alcohol for better treatment, as consumption of alcohol decreases the absorption of vitamin B from the gastrointestinal tract

SIRT1 is NAD-dependent meaning it requires adequate NAD levels to function

High doses might also possibly interfere with levels of other vitamins, enzymes and minerals, which is always a potential problem when taking any nutrient in very large quantities

Monitoring parameters closely and reviewing existing clinical trial data is crucial for designing safe and effective research protocols