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GLP-1 neuronal circuits in hypothalamic appetite regulation and food reward processing Metabolic surgery pharmacology : Studying whether pharmacological dual incretin agonism can replicate the hormonal changes and metabolic benefits of bariatric surgery Cardiovascular research : Elucidating mechanisms of cardiovascular risk reduction via combined GIP/GLP-1 receptor activation NASH/MAFLD research : Exploring effects on hepatic steatosis, inflammation, and fibrosis (SYNERGY-NASH trial ongoing) Peptide engineering : Studying multi-target receptor agonism as a design paradigm how to engineer selectivity ratios across receptor families Comparative pharmacology : Benchmarking dual (GIP/GLP-1) vs
The present analysis used a clinically-relevant approach for HbA1c progression and treatment intensification, which is in line with recent publications and cost-effectiveness assessments of GLP-1 receptor agonists and SGLT2 inhibitors [10, 31]
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Cell Mol
10.3310/hta15suppl1/09 58 SotoJ.GmezA.VsquezM.BarretoA.MolinaK.Zuniga-GonzalezC
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