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Animal Research Context Published preclinical studies typically use 2.5 to 10mcg per kilogram of body weight

Heffernan M, Summers RJ, Thorburn A, et al

This duration of safety monitoring provides meaningful reassurance about sustained exposure effects that would not be apparent in brief trials

Angiogenesis & Microcirculation Used in studies investigating new blood vessel formation, endothelial function, and microvascular stability under various experimental conditions

They may increase the risk of side effects or change the effectiveness of either or both substances