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The PKA and EPAC2 pathways are triggered by both receptors'activation of adenylate cyclase, which raises intracellular cAMP and causes insulin synthesis and release, cellular proliferation, and antiapoptotic effects

Visceral adipocytes possess higher concentrations of growth hormone receptors compared to subcutaneous fat cells

But alongside significant weight loss, another pattern is emerging

doi:10.1016/S0021-9258(18)46868-8

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Phase 2 data, whilst promising, does not constitute sufficient evidence for clinical use outside of a research context