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The initial database search was performed in March 2023, with an update on 25 th April 2024
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Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death
V.2001Antioxidants in health and disease.54176186
To reduce the incidence and progression of these complications, particularly microvascular, glycemic management aiming at blood glucose concentrations close to the normal range has been proved effective 2
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