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up to 1.8%) and body weight compared with placebo and several active treatments, including sitagliptin, exenatide (extended-release), dulaglutide, and insulin glargine.In the SUSTAIN 6 trial, semaglutide also demonstrated CV safety and significantly reduced MACE compared with placebo, confirming its noninferiority while suggesting potential CV protection.[9] 5

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check digoxin level if toxicity suspected | | Oral hypoglycemics: SGLT-2 inhibitors | Pharmacodynamic: additive glucose lowering | Volume depletion additive to GLP-1 natriuresis | Moderate | Ensure adequate hydration

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