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Similarly, tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, demonstrates a dose-dependent gradient of efficacy, with increasing weight reduction observed from 5 to 15 mg weekly [6]
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Lower leptin levels alleviate its inhibitory effects on insulin secretion and improve hepatic insulin sensitivity, while also reducing leptin-driven inflammation (135137)
This observation highlights that endogenous GIP is essential even in type 2 diabetes, suggesting promise for pharmacological agents that target the GIPR
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