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FAO-driven mitochondrial-derived ROS (mROS) depend on the expression of immune-responsive gene 1 (irg1) (61), which has been identified as one of the highly overexpressed genes in acute GA macrophages (62)

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BSH Guidelines for the diagnosis and treatment of cobalamin and folate disorders: Treatment of established cobalamin deciency should follow the schedules in the BNF (Grade 1A)

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In addition to providing protection against oxidative damage, the Trx and GSH systems also play important roles in cell proliferation, redox regulation of gene expression, xenobiotic metabolism, and several other metabolic functions [8,9]