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This regulation occurs via both SMAD-dependent and non-canonical (PI3K/mTORC2/PDGFR) signaling pathways, and is reinforced by Sirtuin-7 downregulation, which reduces Forkhead box protein O4 (FOXO4)-mediated suppression of GLS1 expression [100]
After proliferation submerged culture condition, the first-passage HAECs were seeded in 12-well Transwell plates as previously described (39, 45)
Ablation of ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis
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A 1980 paper in Nature proposed that GHK functions by facilitating copper uptake into cells [4]
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