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These proteins normally exist separately

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Nature Reviews Cancer , 15 (5), 276280

Gallo RL, Huttner KM

Although current guidelines prioritize multimodal therapies based on phenotypic stratification, with pharmacological interventions primarily aimed at alleviating pain and lower urinary tract symptoms (LUTS) (202), select high-quality clinical studies have begun to explore the potential of targeted microenvironment regulation strategies, providing critical evidence for their feasibility

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