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At the CNS level, long-term use of SSRIs could increase extracellular levels of 5-HT by inhibiting SERT, preventing it from degrading to 5-HIAA and thus making more 5-HT available to bind to neuronal 5-HT1A receptors and improve fatigue [395]
But its important to work up to this higher dose of Wellbutrin gradually to prevent side effects
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Your healthcare provider will monitor levels and adjust dosing to maintain optimal ranges without over-supplementation
2016 Jun 9 [cited 2025 Apr 2];127(23):280913
So I mean, its just its going to explode even more than what it has today
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