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Nausea, vomiting, diarrhea, and constipation occur most frequently, particularly during the first month of treatment
The persistent symptoms are hypothesized to be associated with autoimmune disease, rather than hypothyroidism 10
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A typical regimen includes: Weeks 14: 0.25 mg (5 units) once weekly Weeks 58: 0.5 mg (10 units) once weekly Weeks 9+: 1.0 mg (20 units) once weekly This gradual escalation helps minimize gastrointestinal side effects
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