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Research indicates concomitant metformin emerges as a pragmatic maintenance strategy in the postGLP-1 RA period, used in 80% of patients following discontinuation

Cumulative food intake and body weight reduction with either of the agonists were no different from vehicle (Fig

Why GLP-1 (semaglutide or tirzepatide) Might Be Particularly Relevant in Older Adults Cardiometabolic protection Large cardiovascular outcome trials (e.g., SELECT , SUSTAIN-6 ) show semaglutide reduces major adverse cardiovascular events (MACE), and subgroup analyses suggest these benefits extend to older patients

It works by mimicking a hormone called GLP-1, which helps regulate blood sugar levels and reduce appetite