semaglutide major side effects Top 5 Common and How to Minimize Them Wegovy® Side Effects & Safety

Semaglutide can also improve heart failure-related symptoms and inflammation in patients with obesity-related heart failure with preserved ejection fraction (HFpEP), and decrease the risk of major kidney disease events and cardiovascular-related mortality in patients with type 2 diabetes and chronic kidney disease(Butler et al 2024

Managing them ensures you get the most benefit with minimal discomfort

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These include: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite Dyspepsia These effects are broadly consistent with those observed with other GLP-1 receptor agonists and tend to be most pronounced during the initial weeks of treatment

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10.1146/annurev-physiol-021113-170317 Annu