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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)

The tight negative feedback control that glutathione (GSH) exerts on the first of two enzymes responsible for glutathione synthesis, GCL, can explain this phenomenon

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Kurokawa, J