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Additionally, novel compounds such as the SERMs/SERDs hybrid bazedoxifene and the selective ER covalent antagonists are undergoing phase 2 clinical trials for patients experiencing disease progression following advanced endocrine therapy
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Mechanistically, delayed gastric emptying is due to cholinergic inhibition of parasympathetic outflow and nitric oxide (NO) release in a cAMP/PKA-dependent manner [37]
Because they operate through distinct pathways, GHK-Cu and AHK-Cu are complementary rather than redundant
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