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[21] Although the liver is capable of glutamine synthesis, its role in glutamine metabolism is more regulatory than productive, as the liver takes up glutamine derived from the gut via the hepatic portal system

This, in turn, can disrupt metabolic regulation via cytokine-mediated mechanisms and worsen insulin resistance in both maternal and fetal tissues

(2020d)

GLP-1 receptor agonists have shown the ability to reduce neuroinflammation and oxidative stresswell-recognized contributors to Alzheimers diseaseand provide neurotrophic effects in animal models of Alzheimers, the authors write, while cautioning that this needs to be verified by further clinical trials

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