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First, let me caution that this is just a mouse study, so it may not hold true in humans

Starting with lower doses helps minimize any adjustment effects

This is data you can take to your GP or endocrinologist to ask: "Does this explain my symptoms, and should we consider adjusting my levothyroxine before I continue with my weight loss medication?" Always work with your prescribing doctor when it comes to adjusting dosages

If you experience severe or persistent gastrointestinal side effects, talk with your doctor

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It depends on your symptoms, lab results, sleep quality, recovery needs, hormone markers, body composition goals, and medical history