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Guanfacine , an alpha-2A adrenergic agonist first used for blood pressure and now approved in an extended-release form for ADHD, strengthens prefrontal working-memory circuits

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4,207,208 The resultant neuronal hyperexcitability and microglial activation lead to chronic neuropathic pain

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BPC-157 is a synthetic pentadecapeptide a 15-amino-acid sequence corresponding to a partial fragment of a protein identified in gastric juice

While both medications influence these appetite pathways, the way they activate them is where the biggest difference appears