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The same group published extensive evidence for BPC-157s tendon-healing effects, including a mechanistic study demonstrating that BPC-157 promotes tendon outgrowth and cell survival through specific signaling pathways involved in angiogenesis and cell migration [2]

Here, Ekihiro Seki & team implicate the fungal sensing adaptor protein CARD9 in maintaining gut barrier integrity under metabolic stress, finding that the loss of fungal sensing exacerbates liver injury in a murine model of MASLD

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Phase 2 dose-finding trial (Lancet 2021) showed clear dose-response from 0.3 mg up to 4.5 mg/week, but 2.4 mg is the dose Novo Nordisk advanced into Phase 3 and is the most commonly self-reported community ceiling

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in vivo, it did not deliver the obesity outcomes anticipated