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1c) That ASCVD is a chronic inflammatory disease mediated by both the innate and adaptive immune systems, provides potential mechanisms whereby G6PD-d may contribute to atherosclerosis 2

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doi: 10.1016/J.IJBIOMAC.2023.126049 154 SamS.JosephB.ThomasS

Instead of blood vessels or muscle showing through the skin, the skin itself produces melanin (a pigment which darkens to the skin)