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Therapeutic potential of foldamers: from chemical biology tools to drug candidates

Surgery confers multiple downstream benefits: Lower rates of obesity-related comorbidities (like hypertension, hyperlipidemia, sleep apnea) compared to GLP-1 therapy at follow-up JAMA Network Reduced health care utilization: fewer inpatient stays, outpatient visits, and ED visits per patient per month post-surgery compared to GLP-1 therapy

J Cell Biochem , 77:507516

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The molecule was developed by Frank Ng's group at Monash University and Metabolic Pharmaceuticals in Australia during the 1990s and 2000s as a potential anti-obesity drug intended to isolate the lipolytic region of hGH without activating the growth hormone receptor or raising IGF-1.nnIn published preclinical work, the fragment has been shown to stimulate lipolysis, suppress lipogenesis, and modulate the beta-3 adrenergic receptor pathway in adipose tissue rather than acting through the classical hGH receptor

It took me six weeks to start seeing a glow, and even then, only after pairing it with better hydration and sleep