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Anesthesiology 127, 355371

Cyanocobalamin, vitamin B12 preparations containing benzyl alcohol should be avoided in premature neonates because benzyl alcohol has been associated with gasping syndrome, a potentially fatal condition characterized by metabolic acidosis and CNS, respiratory, circulatory, and renal dysfunction

In Phase 3 trials

The prescribing information does not list B12 deficiency as a recognised adverse effect, and clinical trials have not identified a direct mechanistic link between the medication and B12 status

doi:10.1111/luts.12144

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