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1,2 The authors of the review in Biomolecules suggest that larger sample sizes and longer-term studies may help gather clearer results

Activation of mTOR and upregulation of HIF-1 trigger enhanced glycolytic reprogramming in innate immune cells, which fulfills the elevated metabolic demands of trained immunity and synergizes with epigenetic remodeling to sustain the long-term pro-inflammatory and anti-pathogen memory phenotype of innate cells ( C