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GLP-1 receptors are distributed throughout the central nervous system, including regions involved in appetite regulation and reward processing

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These adverse effects can persist for several days, and may result in dehydration, which if severe may lead to other serious health complications.3 Nausea is the most common adverse effect reported with GLP-1 agonists with up to 50 percent of patients affected

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The precise mechanism is not yet fully understood, but may relate to: Blood sugar swings Initial lower calorie consumption Dehydration, particularly if nausea limits the consumption of fluids Many people find that headaches ease after their bodies acclimate to the medication