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Factors that contribute to its development include: Hormonal fluctuations (pregnancy, birth control pills, hormone therapy) Genetic predisposition UV exposure and photoaging Emotional stress Sleep disturbances Photosensitizing medications Chronic inflammation What makes melasma particularly frustrating is its multifaceted nature
PubMed laboratory research record [PMID: 34356886] PubMed record related to this compound for laboratory literature review
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Annu Rev Pharmacol Toxicol , 45:5188
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This can include drug metabolites, heavy metals, pesticides/herbicides, xenoestrogens like BPA, alcohol, and other toxic chemicals
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