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In PIONEER 3 and 7, oral semaglutide 7 mg, 14 mg, and flexibly dosed significantly reduced HbA 1c and body weight compared with sitagliptin 100 mg (up to week 52 in PIONEER 7 and week 78 in PIONEER 3) [7, 10]
One strategy some research users report is maintaining a lower maintenance dose rather than stopping entirely, similar to how the clinical trial community is now discussing long-term low-dose maintenance for GLP-1 class medications broadly
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Skipping this step is the fastest way to introduce contamination into your solution
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