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Due to the medication mimicking 3 hormones, it may have a stronger appetite suppression effect

Zepbound is administered as a once-weekly subcutaneous injection, with dosing typically starting at 2.5 mg for 4 weeks, then increasing by 2.5 mg every 4 weeks as tolerated (through intermediate steps of 5 mg, 7.5 mg, 10 mg, 12.5 mg) to a maintenance dose of 5 mg, 10 mg, or 15 mg based on individual response and tolerability

Similarly, post hoc analyses of Harmony Outcomes and DECLARETIMI 58 suggested preserved benefit with concomitant therapy, but these studies were not powered to establish additive efficacy of the combination [26, 27]

Semaglutide is designed for long-term use, so you dont have to worry about bounce-back weight gain

Very heavy bleeding (menorrhagia): Soaking through sanitary products every one to two hours, passing large clots, or bleeding that lasts longer than seven days may indicate anaemia risk or other pathology requiring investigation

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