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Silvagno et al., 2020)

Except for some symptoms such as headache and a few specific reactions (vomiting, vagal reactions, hypotension, discomfort, and arousal: one each) observed during alcohol and opioid withdrawal, DSIP has been well-tolerated during administration

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Autism spectrum disorder: a review

It even has its own name - Intestinal Methanogen Overgrowth (IMO)