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This mechanism helps to reduce postprandial blood glucose spikes

Endocrinology 150: 1155-1164, 2009

(6) Cohen SB, Short CP, OHagan T, Wu HT, Morrison WB, Zoga AC

After propensity score matching, over 20,000 patients receiving GLP-1 receptor agonists were compared with a matched cohort not using these medications

It was found that meta-substitution of the phenyl ring with a sulfamoyl group enhanced the DPP-4 inhibitory activity of the lead compound 56 (Figure 7)