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Gastrointestinal symptoms (nausea, diarrhea, constipation, abdominal pain) are most common, typically occurring during dose escalation and often improving with continued use
Tirzepatide is newer, and while compounded tirzepatide became available as the brand-name version faced supply constraints, its availability and pricing have varied more
Melanotan II thus indirectly led to an approved drug, although it itself remained a research peptide
Some patients may experience palpitations, particularly during the initial weeks of GLP-1 therapy
