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Clinical effectiveness of currently used antidepressant drugs, which target monoaminergic systems in the brain mainly by enhancing serotoninergic and noradrenergic neurotransmission, is very often low and insufficient since approximately only one-third of the patients achieve complete remission of depressive symptoms after therapy

Genetic diversity of viable, injured, and dead fecal bacteria assessed by fluorescence-activated cell sorting and 16S rRNA gene analysis

Animal studies show CNS concentrations 34 higher than KPV at equivalent systemic doses

Correcting these can modestly improve symptoms, particularly inattention and hyperactivity

Nature Reviews Molecular Cell Biology , 22, 266282

doi:10.1038/npp.2014.326