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Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, et al
On the other hand, the most abundant DPP-IV-processed metabolite GLP-1 (9-36) NH2 , has also been reported to have biological activities, protecting human aortic endothelial cells and cardiomyocytes in vivo in dogs (137) and ex vivo in mice (138) and rats (139), even in the absence of a GLP-1 Receptor (140, 139)
By activating these receptors, GLP-1 agonists initiate a cascade of physiological responses that collectively improve glycaemic control, promote weight loss, and confer additional cardiometabolic benefits
Because different GLP-1 agonists have different FDA-labeled indications, they may be used for different reasons, such as type 2 diabetes or weight loss
S., W, Aboumarzouk, O
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