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This evidence cautions against short-term use of weight management medications, emphasises the need for further research into cost effective strategies for long-term weight control, and reinforces the importance of primary prevention. In response, Dr Trevor Steward, a senior research fellow in the School of Psychological Sciences at the University of Melbourne, said the analysis confirms what many doctors have experienced in the real world, that weight often returns after patients stop their medications

1999 May;134(5):607-13

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In Phase 2/3 clinical trials, participants lost an average of 24-29% of body weight at the highest doses (8-12 mg) over 48-68 weeks

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Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk