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Translating a 15 mg/kg murine dose directly to humans underscores a severe translational gap in the source paper

Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)

They stay in your body longer and in higher amounts than the natural GLP-1 your body produces

Another associated condition is Neurocutaneous melanosis, where these nevi are associated with excessive growth of melanocytes in the nervous system

Frontiers in endocrinology 12 , 741764 (2021)

A greenish, teal or brown shift indicates that copper has dropped out of the chelate, which is a discard signal