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Three amino acids make up it: glycine, cysteine, and glutamine
GPX4 plays a critical role in protecting retinal cells against oxidative stress and ferroptosis-associated damage (78)
Glutathione biosynthesis is facilitated by a rate-limiting enzyme, glutamate-cysteine ligase (GCL), which consists of a catalytic subunit (GCLC) and a modifier subunit (GCLM)
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ROS exert cellular toxicity by modifying DNA, lipids, and proteins through DNA base oxidation, lipid peroxidation, and protein carbonylation (protein oxidation), respectively 7,8,9
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