GLP-1s and Endurance Performance: What Athletes Need to Know Dec 10, 2025 GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) have quickly gained attention for their dramatic effects on weight loss and appetite control
It is FDA-approved for the treatment of Type 2 diabetes and works by enhancing insulin secretion, reducing glucagon levels, slowing gastric emptying, and increasing satiety
Dosage goes up incrementally: 0.25mg Starter dose taken once weekly for the first 4 weeks to help your body adjust and reduce the risk of side effects 0.5mg Second step dose, usually taken for 4 weeks, allowing your body to continue adapting 1mg Mid escalation dose that begins to deliver stronger appetite suppression 1.7mg Higher step up dose used before reaching maintenance, supporting increased effectiveness 2.4mg Typical maintenance dose for long-term weight management and maximum clinical benefit In the first few weeks, many people feel full sooner during meals and are less tempted by large portions or late-night snacks
But other indulgent treat manufacturers have seen negligible changes, with PepsiCo CEO Ramon Laguarta telling analysts last month the company hasnt seen a direct impact from GLP-1 medications
This doesnt make GLP-1s useless it makes them a supportive tool rather than a solution
While adverse reactions are uncommon, individual sensitivities can occur with any supplement, particularly multi-ingredient formulas