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Not effective for individuals with severe deficiencies

Ed.) 283 , 1435 (1981)

Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione

At month 1, improvement was minimal (~10 hairs)

Therefore, while glutathione is generally considered safe, there can be potential side effects to be considered with its use

Since there was no significant difference of the mRNA level of GCS-HS and GS between control and proline group at any time points, it can be assumed that the activity of GCS in proline group might be upregulated by the upregulation of regulatory subunit of GCS, leading to the significant upregluation of total GSH from 6 h to 12 h