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doi: 10.1016/j.molcel.2005.12.016 185 WangCMayerJAMazumdarAFertuckKKimHBrownMet al
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in pancreatic delta cells, do not yield detectable protein expression ( Glp1r promoter-dependent Cre recombinase leads to fluorescent protein expression, have also been used to map GLP-1R-containing cell types ( Glp1r reporter mouse ( Human GLP-1R comprises 463 amino acids, including an N-terminal signal peptide that is cleaved on delivery to the plasma membrane ( G s /cAMP/PKA Signalling in Beta Cells Canonical GLP-1R signalling occurs via heterotrimeric G proteins, comprising an independent G subunit and a G/ dimer bound reversibly to G
These variations do not impact the overall quality and efficacy of the product
& Jones, J
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