Side effect profiles: Both medications share GI side effects (nausea, vomiting, diarrhea), but semaglutide's slower titration schedule tends to produce better long-term tolerability
Rapid or significant weight loss can sometimes leave loose or lax skin, particularly on the abdomen, arms and thighs
ClinicalTrials.gov lists multiple registered studies, including NCT06939088 examining tirzepatide effects on alcohol intake, and NCT06994338 investigating tirzepatide specifically for alcohol use disorder
Seven additional Phase 3 trials are expected to complete in 2026
Pros: Completely virtual prescription process No contracts Fixed monthly payments Overnight shipping Cons: Doesnt take insurance Not available in all U.S
Here are the most common side effects: Nausea : This is the most frequently reported side effect, affecting up to half of the people who use GLP-1s